TBCE Antibody

• Background:

  Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.

• NCBI Gene ID:

  6905

• Swiss Prot:

  Q15813

• Accession Number:

  Q15813

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TBCE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-392 amino acids from the Central region of human TBCE.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  59 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TBCE

• NCBI Official Name:

  Tubulin-specific chaperone E

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Biernacki, M.A., et al. Cancer Res. 70 (3) :906-915 (2010)

• Background Reference 02:

  Padidela, R., et al. J. Clin. Endocrinol. Metab. 94 (8) :2686-2691 (2009)

• Background Reference 03:

  Lindgren, C.M., et al. PLoS Genet. (6), E1000508 (2009)

• Background Reference 04:

  Jin, S., et al. Development 136 (9) :1571-1581 (2009)

• Other Product Names:

  Tubulin-specific chaperone E, Tubulin-folding cofactor E, TBCE

• Tested Applications:

  WB

• Protein ID:

  74762146

• Physical Properties:

  Liquid