PTPN2 Antibody

• Background :

  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. [provided by RefSeq].

• NCBI Gene ID :

  5771

• Swiss Prot :

  P17706

• Accession Number :

  P17706

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This PTPN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-358 amino acids from the C-terminal region of human PTPN2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  48 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  PTPN2

• NCBI Official Name :

  Tyrosine-protein phosphatase non-receptor type 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Scharl, M., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (4), G935-G945 (2010) :

• Background Reference 02 :

  Morgan, A.R., et al. Tissue Antigens 76 (2) :119-125 (2010)

• Background Reference 03 :

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 04 :

  Kleppe, M., et al. Nat. Genet. 42 (6) :530-535 (2010)

• Other Product Names :

  Tyrosine-protein phosphatase non-receptor type 2, T-cell protein-tyrosine phosphatase, TCPTP, PTPN2, PTPT

• Tested Applications :

  WB, IHC-P

• Protein ID :

  229462762

• Physical Properties :

  Liquid