Products for Research Use Only
RegisterLogin

PTPN2 Antibody

CAT: 0223-56-980Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-56-980Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. [provided by RefSeq].
NCBI Gene ID
5771
Swiss Prot
P17706
Accession Number
P17706
Host
Rabbit
Reactivity
Human
Immunogen
This PTPN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-358 amino acids from the C-terminal region of human PTPN2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
48 kDa
Fragment
Rabbit Ig
Symbol
PTPN2
NCBI Official Name
Tyrosine-protein phosphatase non-receptor type 2
NCBI Organism
Homo sapiens
Background Reference 01
Scharl, M., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (4), G935-G945 (2010) :
Background Reference 02
Morgan, A.R., et al. Tissue Antigens 76 (2) :119-125 (2010)
Background Reference 03
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 04
Kleppe, M., et al. Nat. Genet. 42 (6) :530-535 (2010)
Other Product Names
Tyrosine-protein phosphatase non-receptor type 2, T-cell protein-tyrosine phosphatase, TCPTP, PTPN2, PTPT
Tested Applications
WB, IHC-P
Protein ID
229462762
Physical Properties
Liquid

Related Products

CatalogName
61-166PTPN12 Antibody
19-261PTPN4 Antibody
15-553PTPN6 Antibody
15-350PTPN22 Antibody
8013-01PTPN5 Antibody
XW-7826PTPN1 Antibody
63-024PTPN7 Antibody
22-190PTPN3 Antibody
61-522PTPN6 Antibody
60-913PTPN1 Antibody

Alternative Products

CatalogName
70R-19641PTPN2 antibody

Popular Products