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PTPN7 Antibody

CAT: 0223-63-024Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-024Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PTPN7 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN7 is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP has been shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which is thought to function through dephosphorylating the molecules related to MAP kinase pathway.
NCBI Gene ID
5778
Swiss Prot
P35236
Accession Number
P35236
Host
Rabbit
Reactivity
Human
Immunogen
This PTPN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-51 amino acids from human PTPN7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
41 kDa
Fragment
Rabbit Ig
Symbol
PTPN7
NCBI Official Name
Tyrosine-protein phosphatase non-receptor type 7
NCBI Organism
Homo sapiens
Background Reference 01
Eswaran, J., Biochem. J. 395 (3), 483-491 (2006)
Background Reference 02
Mustelin, T., J. Mol. Biol. 354 (1), 150-163 (2005)
Background Reference 03
Pettiford, S.M., Leukemia 17 (2), 366-378 (2003)
Background Reference 04
Kosaki, K., J. Clin. Endocrinol. Metab. 87 (8), 3529-3533 (2002)
Other Product Names
Tyrosine-protein phosphatase non-receptor type 7, Hematopoietic protein-tyrosine phosphatase, HEPTP, Protein-tyrosine phosphatase LC-PTP, PTPN7
Tested Applications
WB, IHC-P
Protein ID
20141721
Physical Properties
Liquid

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