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PTPN6 Antibody

CAT: 0223-61-522Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-522Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PTPN6 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.
NCBI Gene ID
5777
Swiss Prot
P29350
Accession Number
P29350
Host
Rabbit
Reactivity
Human
Immunogen
This PTPN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-277 amino acids from the Central region of human PTPN6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
68 kDa
Fragment
Rabbit Ig
Symbol
PTPN6
NCBI Official Name
Tyrosine-protein phosphatase non-receptor type 6
NCBI Organism
Homo sapiens
Background Reference 01
Korporaal, S.J., Arterioscler. Thromb. Vasc. Biol. 29 (3), 372-379 (2009)
Background Reference 02
Cho, Y.S., Am. J. Respir. Cell Mol. Biol. 39 (4), 412-419 (2008)
Background Reference 03
Christophi, G.P., Lab. Invest. 88 (3), 243-255 (2008)
Background Reference 04
Jones, M.L., J. Biol. Chem. 279 (39), 40475-40483 (2004)
Other Product Names
Tyrosine-protein phosphatase non-receptor type 6, Hematopoietic cell protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1C, PTP-1C, Protein-tyrosine phosphatase SHP-1, SH-PTP1, PTPN6, HCP, PTP1C
Tested Applications
WB, IHC-P, IF
Protein ID
131469
Physical Properties
Liquid

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