Products for Research Use Only
RegisterLogin

PTPN5 Antibody

CAT: 0223-8013-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-8013-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The protein tyrosine phosphatase PTPN5, also known as Striatal enriched phosphatase (STEP), is involved in the regulation of synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors (1) . It is expressed in dopaminoceptive neurons of the central nervous system and multiple forms of PTPN5 show differential enrichment in adult brain regions (2) . NMDA-mediated activation of PTPN5 is an important mechanism for regulation of Erk activity in neurons (3) . Furthermore, PTPN5 is involved in the regulation of both NMDAR and AMPAR trafficking (4,5) . PTPN5 may play a role in Alzheimer's disease (1) .
NCBI Gene ID
84867
Swiss Prot
Q86TL6
Accession Number
NP_008837
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
PTPN5 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
1 mg/mL
Buffer
PTPN5 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PTPN5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
PTPN5 antibody is human and mouse reactive.
Symbol
PTPN5
NCBI Official Name
Protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
NCBI Organism
Homo sapiens
Background Reference 01
Braithwaite SP, Paul S, Nairn AC, et al. Synaptic plasticity: one STEP at a time. Trends Neurosci. 2006; 29:452-8.
Background Reference 02
Paul S, Snyder GL, Yokakura H, et al. The Dopamine/D1 receptor mediates the phosphorylation and inactivation of the protein tyrosine phosphatase STEP via a PKA-dependent pathway. J. Neurosci. 2000; 20:5630-8.
Background Reference 03
Paul S, Nairn AC, Wang P, et al. NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat. Neurosci. 2003; 6:34-42.
Background Reference 04
Braithwaite SP, Adkisson M, Leung J, et al. Regulation of NMDA receptor trafficking and function by striatal-enriched tyrosine phosphatase (STEP) . Eur. J. Neurosci. 2006; 23:2847-56.
Other Product Names
Tyrosine-protein phosphatase non-receptor type 5, Neural-specific protein-tyrosine phosphatase, PTPSTEP, Striatum-enriched protein-tyrosine phosphatase, STEP
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
90652859
Physical Properties
Liquid

Related Products

CatalogName
8013PPTPN5 Peptide
30-062PTPN2 Antibody
30-061PTPN2 Antibody
19-261PTPN4 Antibody
15-553PTPN6 Antibody
XW-7826PTPN1 Antibody
63-024PTPN7 Antibody
22-190PTPN3 Antibody
61-522PTPN6 Antibody
60-913PTPN1 Antibody

Alternative Products

CatalogName
70R-6729PTPN5 antibody

Popular Products