CDKN1B Antibody

• Background:

  This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].

• NCBI Gene ID:

  1027

• Swiss Prot:

  P46527

• Accession Number:

  P46527

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CDKN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-176 amino acids from the C-terminal region of human CDKN1B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  22 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CDKN1B

• NCBI Official Name:

  Cyclin-dependent kinase inhibitor 1B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kajihara, R., et al. Biochem. Biophys. Res. Commun. 401 (3) :350-355 (2010) Kedde, M., et al. Nat. Cell Biol. 12 (10) :1014-1020 (2010) Canbay, E., et al. Anticancer Res. 30 (7) :3093-3098 (2010) Do Nascimento Borges, B., et al. In Vivo 24 (4) :579-582 (2010) Qin, J., et al. Hepatogastroenterology 57 (99-100), 547-553 (2010) :

• Other Product Names:

  Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, CDKN1B, KIP1

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid