CDKN2B Antibody

CAT: 0223-31-041Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-31-041Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CDKN2B's gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B is a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition.
NCBI Gene ID
1030
Swiss Prot
P42772
Accession Number
NP_004927
Host
Rabbit
Reactivity
Human
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CDKN2B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Cancer, Apoptosis
Purification
Antibody is purified by peptide affinity chromatography method.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
Batch dependent
Buffer
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
For short periods of storage (days) store at 4˚ C. For longer periods of storage, store CDKN2B antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Calculated Molecular Weight
15 kDa
Applications Notes
CDKN2B antibody can be used for detection of CDKN2B by ELISA at 1:2500. CDKN2B antibody can be used for detection of CDKN2B by western blot at 1.0 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Symbol
CDKN2B
NCBI Official Name
Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
NCBI Organism
Homo sapiens
Background Reference 01
Scott, S.A., et al., (2004) Leuk. Res. 28 (12), 1293-1301.
Other Product Names
CDKN2B, P15, MTS2, TP15, CDK4I, INK4B, p15INK4b
Tested Applications
ELISA, WB
Protein ID
17981694
Physical Properties
Liquid

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