Products for Research Use Only
RegisterLogin

CDKN1C Antibody

CAT: 0223-7015-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-7015-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
CDKN1C Antibody: The cyclin-dependent kinase inhibitor 1C (CDKN1C), also known as p57KIP2, is a tight-binding, strong inhibitor of several G1 cyclin/CDK complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndrome, a cancer-predisposing syndrome, suggesting that this gene is a tumor suppressor candidate. CDKN1C is widely expressed during organogenesis with its expression declining after maturity. It is part of the CIP/KIP family of cyclin-dependent inhibitors (CKIs) which also includes CDKN1A and CDKN1B.
NCBI Gene ID
1028
Swiss Prot
P49918
Accession Number
NP_000067
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
CDKN1C Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (88%)
Buffer
CDKN1C Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CDKN1C antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
35 kDa
Fragment
IgG
Specificity
At least three isoforms of CDKN1C are known to exist; this antibody will detect all three isoforms. Despite its predicted molecular weight, CDKN1C often migrates at 57kDa in SDS-PAGE. CDKN1C antibody is predicted to not cross react with other CIP/KIP proteins.
Symbol
CDKN1C
Positive Control 2
Cat. No. 17-010 - HEK293 Cell Slide
NCBI Official Name
Cyclin-dependent kinase inhibitor 1C (p57, Kip2)
NCBI Organism
Homo sapiens
Background Reference 01
Lee MH, Reynisdottir I, and Massague J. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev. 1995; 9:639-49.
Background Reference 02
Pateras IS, Apostolopoulou K, Niforou K, et al. p57KIP2: “Kip"ing the cell under control. Mol. Cancer Res. 2009; 1902-19
Background Reference 03
Hatada I, Ohashi H, Fukushima Y, et al. An imprinted p57KIP2 is mutated in Beckwith-Wiedemann syndrome. Nat. Genet. 1996; 14:171-3.
Other Product Names
CDKN1C Antibody: BWS, WBS, p57, BWCR, KIP2, p57Kip2, Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57
Tested Applications
ELISA, WB, IF
Protein ID
4557441
Physical Properties
Liquid

Related Products

CatalogName
7015PCDKN1C Peptide
15-754CDKN1A Antibody
55-525CDKN2C Antibody
18-463CDKN2C Antibody
15-105CDKN1B Antibody
45-032CDKN1B Antibody
14-025CDKN1A Antibody
56-976CDKN1B Antibody
14-410CDKN2C Antibody
13-132CDKN1B Antibody

Alternative Products

CatalogName
MBS8590135-01CDKN1C Antibody

Popular Products