CDKN2B Antibody

• Background:

  This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

• NCBI Gene ID:

  1030

• Swiss Prot:

  P42772

• Accession Number:

  P42772

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CDKN2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human CDKN2B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  15 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CDKN2B

• NCBI Official Name:

  Cyclin-dependent kinase 4 inhibitor B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Camacho, C.V., et al. Carcinogenesis 31 (10) :1889-1896 (2010)

• Background Reference 02:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03:

  Pechlivanis, S., et al. Arterioscler. Thromb. Vasc. Biol. 30 (9) :1867-1872 (2010)

• Background Reference 04:

  Heni, M., et al. Diabetes (2010) In press :

• Other Product Names:

  Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2, MTS-2, p14-INK4b, p15-INK4b, p15INK4B, CDKN2B, MTS2

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  1168869

• Physical Properties:

  Liquid