CDKN2B Antibody

CAT: 0223-56-550Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-550Size:400 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
NCBI Gene ID
1030
Swiss Prot
P42772
Accession Number
P42772
Host
Rabbit
Reactivity
Human
Immunogen
This CDKN2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human CDKN2B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
15 kDa
Fragment
Rabbit Ig
Symbol
CDKN2B
NCBI Official Name
Cyclin-dependent kinase 4 inhibitor B
NCBI Organism
Homo sapiens
Background Reference 01
Camacho, C.V., et al. Carcinogenesis 31 (10) :1889-1896 (2010)
Background Reference 02
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 03
Pechlivanis, S., et al. Arterioscler. Thromb. Vasc. Biol. 30 (9) :1867-1872 (2010)
Background Reference 04
Heni, M., et al. Diabetes (2010) In press :
Other Product Names
Cyclin-dependent kinase 4 inhibitor B, Multiple tumor suppressor 2, MTS-2, p14-INK4b, p15-INK4b, p15INK4B, CDKN2B, MTS2
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
1168869
Physical Properties
Liquid

Related Products

CatalogName
42-917Cdkn2a Antibody
24-023CDKN2A Antibody
22-309CDKN2D Antibody
4211-002mgCDKN2A Antibody
8975-01CDKN2A Antibody
45-032CDKN1B Antibody
45-033CDKN2A Antibody
49-544CDKN2A Antibody
8975-002mgCDKN2A Antibody
55-525CDKN2C Antibody

Alternative Products

CatalogName
MBS7001867-01CDKN2B Antibody
MBS9433792-01CDKN2B Polyclonal Antibody
558170-01CDKN2B

Popular Products