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NDST1 Antibody

CAT: 0223-56-931Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-931Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NDST1 is an essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response.
NCBI Gene ID
3340
Swiss Prot
P52848
Accession Number
P52848
Host
Rabbit
Reactivity
Human
Immunogen
This NDST1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 820-849 amino acids from the C-terminal region of human NDST1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
101 kDa
Fragment
Rabbit Ig
Symbol
NDST1
NCBI Official Name
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
NCBI Organism
Homo sapiens
Background Reference 01
Yoshida, T., et al. Int. J. Mol. Med. 25 (4) :649-656 (2010)
Background Reference 02
Oguri, M., et al. Am. J. Hypertens. 23 (1) :70-77 (2010)
Background Reference 03
Duelli, A., et al. J. Immunol. 183 (11) :7073-7083 (2009)
Background Reference 04
Zuberi, R.I., et al. J. Immunol. 183 (6) :3971-3979 (2009)
Other Product Names
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1, Glucosaminyl N-deacetylase/N-sulfotransferase 1, NDST-1, N-heparan sulfate sulfotransferase 1, N-HSST 1, [Heparan sulfate]-glucosamine N-sulfotransferase 1, HSNST 1, Heparan sulfate N-deacetylase 1, 3---, Heparan sulfate N-sulfotransferase 1, 282-, NDST1, HSST, HSST1
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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