NDST4 Antibody

• Background:

  Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA dissacharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity) .

• NCBI Gene ID:

  64579

• Swiss Prot:

  Q9H3R1

• Accession Number:

  Q9H3R1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This NDST4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-212 amino acids from the N-terminal region of human NDST4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  101 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  NDST4

• NCBI Official Name:

  Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Kalsi, G., et al. Hum. Mol. Genet. 19 (12) :2497-2506 (2010)

• Background Reference 03:

  Treutlein, J., et al. Arch. Gen. Psychiatry 66 (7) :773-784 (2009)

• Background Reference 04:

  Aikawa, J., et al. J. Biol. Chem. 276 (8) :5876-5882 (2001)

• Other Product Names:

  Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4, Glucosaminyl N-deacetylase/N-sulfotransferase 4, NDST-4, N-heparan sulfate sulfotransferase 4, N-HSST 4, Heparan sulfate N-deacetylase 4, 3---, Heparan sulfate N-sulfotransferase 4, 282-, NDST4, HSST4

• Tested Applications:

  WB

• Protein ID:

  74718249

• Physical Properties:

  Liquid