NDST2 Antibody

• Background:

  The N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 (NDST2) protein, also known as N-heparan sulfate sulfotransferase 2, and the highly related protein NDST1 have key roles in the sulfation of heparan sulfate proteoglycans, molecules that are present of cell surfaces and the extracellular matrix (1,2) . NDST1 and NDST2 are dispensable for mesodermal differentiation into osteoblasts but necessary for induction of adipocytes and neural cells (3) .

• NCBI Gene ID:

  8509

• Swiss Prot:

  P52849

• Accession Number:

  NP_003626

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  NDST2 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1288 - A20 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (100%)

• Buffer:

  NDST2 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  NDST2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  NDST2 antibody is human, mouse and rat reactive. At least two isoforms of NDST2 are known to exist; this antibody will only detect the larger isoform. NDST2 antibody is predicted not to cross-react with other members of the NDST protein family.

• Symbol:

  NDST2

• NCBI Official Name:

  N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Humphries DE, Lanciotti J, and Karlinsky JB. cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2. Biochem. J. 1998; 332:303-7.

• Background Reference 02:

  Esko JD and Selleck SB. Order out of chaos. Assembly of ligand binding sites in heparan sulfate. Annu. Rev. Biochem. 2002; 71:435-71.

• Background Reference 03:

  Forsberg M, Holmborn K, Kundu S, et al. Undersulfation of heparan sulfate restricts differentiation potential of mouse embryonic stem cells. J. Biol. Chem. 2012; 287:10853-62.

• Other Product Names:

  NDST2 Antibody: NST2, HSST2, N-heparan sulfate sulfotransferase 2, NDST-2

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  4505353

• Physical Properties:

  Liquid