CDH19 Antibody

• Background:

  This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes.

• NCBI Gene ID:

  28513

• Swiss Prot:

  Q9H159

• Accession Number:

  Q9H159

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CDH19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613-640 amino acids from the C-terminal region of human CDH19.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  87 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CDH19

• NCBI Official Name:

  Cadherin-19

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Need, A.C., et al. Hum. Mol. Genet. 18 (23) :4650-4661 (2009)

• Background Reference 02:

  Clark, H.F., et al. Genome Res. 13 (10) :2265-2270 (2003)

• Background Reference 03:

  Kools, P., et al. Genomics 68 (3) :283-295 (2000)

• Background Reference 04:

  Shimoyama, Y., et al. Biochem. J. 349 (PT 1), 159-167 (2000) :

• Other Product Names:

  Cadherin-19, CDH19, CDH7L2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  17366818

• Physical Properties:

  Liquid