CDH16 Antibody

• Background:

  This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.

• NCBI Gene ID:

  1014

• Swiss Prot:

  O75309

• Accession Number:

  O75309

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CDH16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 796-824 amino acids from the C-terminal region of human CDH16.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  90 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CDH16

• NCBI Official Name:

  Cadherin-16

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Thedieck, C., et al. J. Mol. Biol. 378 (1) :145-153 (2008)

• Background Reference 02:

  Kuehn, A., et al. Am. J. Surg. Pathol. 31 (10) :1528-1533 (2007)

• Background Reference 03:

  Thedieck, C., et al. Br. J. Cancer 92 (11) :2010-2017 (2005)

• Background Reference 04:

  Hishikawa, K., et al. Biochem. Biophys. Res. Commun. 328 (1) :288-291 (2005)

• Other Product Names:

  Cadherin-16, Kidney-specific cadherin, Ksp-cadherin, CDH16

• Tested Applications:

  WB

• Physical Properties:

  Liquid