CDH11 Antibody

• Background:

  This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.

• NCBI Gene ID:

  1009

• Swiss Prot:

  P55287

• Accession Number:

  P55287

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This CDH11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 622-650 amino acids from the C-terminal region of human CDH11.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  88 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CDH11

• NCBI Official Name:

  Cadherin-11

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Sachdeva, M., et al. Cancer Res. 70 (1) :378-387 (2010)

• Background Reference 03:

  Canova, C., et al. Cancer Res. 69 (7) :2956-2965 (2009)

• Background Reference 04:

  Farina, A.K., et al. PLoS ONE (3), E4797 (2009) :

• Other Product Names:

  Cadherin-11, OSF-4, Osteoblast cadherin, OB-cadherin, CDH11

• Tested Applications:

  WB

• Protein ID:

  146345381

• Physical Properties:

  Liquid