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PUS1 Antibody

CAT: 0223-56-681Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-681Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. The encoded enzyme may play an essential role in tRNA function and in stabilizing the secondary and tertiary structure of many RNAs. A mutation in this gene has been linked to mitochondrial myopathy and sideroblastic anemia. Alternate splicing results in multiple transcript variants.
NCBI Gene ID
80324
Swiss Prot
Q9Y606
Accession Number
Q9Y606
Host
Rabbit
Reactivity
Human
Immunogen
This PUS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-350 amino acids from the C-terminal region of human PUS1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
47 kDa
Fragment
Rabbit Ig
Symbol
PUS1
NCBI Official Name
TRNA pseudouridine synthase A, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Bergmann, A.K., et al. Pediatr Blood Cancer 54 (2) :273-278 (2010)
Background Reference 02
Sibert, B.S., et al. RNA 14 (9) :1895-1906 (2008)
Background Reference 03
Rikova, K., et al. Cell 131 (6) :1190-1203 (2007)
Background Reference 04
Sugiyama, N., et al. Mol. Cell Proteomics 6 (6) :1103-1109 (2007)
Other Product Names
TRNA pseudouridine synthase A, mitochondrial, tRNA pseudouridine (38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I, PUS1
Tested Applications
WB, IHC-P
Protein ID
114152895
Physical Properties
Liquid

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