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PUS10 Antibody

CAT: 0223-60-817Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-817Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al., 2007 [PubMed 17900615]) .[supplied by OMIM].
NCBI Gene ID
150962
Swiss Prot
Q3MIT2
Accession Number
Q3MIT2
Host
Rabbit
Reactivity
Human
Immunogen
This PUS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-78 amino acids from the N-terminal region of human PUS10.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
60 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PUS10
NCBI Official Name
Putative tRNA pseudouridine synthase Pus10
NCBI Organism
Homo sapiens
Background Reference 01
Dick, D.M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :
Background Reference 02
McGovern, D.P., et al. Nat. Genet. 42 (4) :332-337 (2010)
Background Reference 03
Dubois, P.C., et al. Nat. Genet. 42 (4) :295-302 (2010)
Background Reference 04
Hosgood, H.D. III, et al. Occup Environ Med 66 (12) :848-853 (2009)
Other Product Names
Putative tRNA pseudouridine synthase Pus10, 5499-, Coiled-coil domain-containing protein 139, tRNA pseudouridine 55 synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase, PUS10, CCDC139, DOBI
Tested Applications
WB
Protein ID
121942830
Physical Properties
Liquid

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