PHAX Antibody

CAT: 0223-56-680Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-680Size:400 µL
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Background
A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC) -bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity) . Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA) . Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG) -capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.
NCBI Gene ID
51808
Swiss Prot
Q9H814
Accession Number
Q9H814
Host
Rabbit
Reactivity
Human
Immunogen
This PHAX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 297-326 amino acids from the C-terminal region of human PHAX.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Symbol
PHAX
NCBI Official Name
Phosphorylated adapter RNA export protein
NCBI Organism
Homo sapiens
Background Reference 01
Mourao, A., et al. RNA 16 (6) :1205-1216 (2010)
Background Reference 02
Matsuoka, S., et al. Science 316 (5828) :1160-1166 (2007)
Background Reference 03
Lemm, I., et al. Mol. Biol. Cell 17 (7) :3221-3231 (2006)
Background Reference 04
Watkins, N.J., et al. Mol. Cell 16 (5) :789-798 (2004)
Other Product Names
Phosphorylated adapter RNA export protein, RNA U small nuclear RNA export adapter protein, PHAX, RNUXA
Tested Applications
WB, IHC-P
Protein ID
74752718
Physical Properties
Liquid

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