PHAP Antibody

CAT: 0223-3149-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-3149-01Size:0.02 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
PHAP Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
NCBI Gene ID
8125
Swiss Prot
P39687
Accession Number
P39687
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
PHAP Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1207 - Raji Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Sheep: (100%), Bovine: (100%)
Buffer
PHAP Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PHAP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
ANP32A
Positive Control 2
Cat. No. 17-007 - Raji Cell Slide
NCBI Official Name
Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
NCBI Organism
Homo sapiens
Background Reference 01
Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC , Rosenberg S, Wang X. Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science. 2003;299 (5604) :223-6.
Background Reference 02
Nicholson DW, Thornberry NA. Apoptosis. Life and death decisions. Science. 2003 10;299 (5604) :214-5.
Other Product Names
PHAP Antibody: LANP, MAPM, PP32, HPPCn, PHAP1, PHAPI, I1PP2A, C15orf1, LANP, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32
Tested Applications
ELISA, WB, IHC-P
Protein ID
730318
Physical Properties
Liquid

Related Products

CatalogName
3151-002mgPHAP I Antibody
3151-01PHAP I Antibody
3147-01mgPHAP III Antibody
3147-01PHAP III Antibody
3145-002mgPHAP I Antibody
3145-01mgPHAP I Antibody
3151-01mgPHAP I Antibody
3147-002mgPHAP III Antibody
3145-01PHAP I Antibody
3149PPHAP Peptide

Alternative Products

CatalogName
MBS9407934-01PHAP Antibody
MBS9412967-01PHAP I Antibody
APR09077GPolyclonal PHAP Antibody
24196PHAP III Antibody
11082Anti-PHAP I (IN) Antibody
APR09080GPolyclonal PHAP I Antibody
APR09082GPolyclonal PHAP III Antibody
11090Anti-PHAP (CT) Antibody
11084Anti-PHAP III Antibody
MBS152207-01PHAP Peptide

Popular Products