PHAP Antibody

• Background :

  PHAP Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.

• NCBI Gene ID :

  8125

• Swiss Prot :

  P39687

• Accession Number :

  P39687

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Apoptosis

• Purification :

  PHAP Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1207 - Raji Cell Lysate

• Concentration :

  1 mg/mL

• Homology :

  Predicted species reactivity based on immunogen sequence: Sheep: (100%), Bovine: (100%)

• Buffer :

  PHAP Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  PHAP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Symbol :

  ANP32A

• Positive Control 2 :

  Cat. No. 17-007 - Raji Cell Slide

• NCBI Official Name :

  Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC , Rosenberg S, Wang X. Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science. 2003;299 (5604) :223-6.

• Background Reference 02 :

  Nicholson DW, Thornberry NA. Apoptosis. Life and death decisions. Science. 2003 10;299 (5604) :214-5.

• Other Product Names :

  PHAP Antibody: LANP, MAPM, PP32, HPPCn, PHAP1, PHAPI, I1PP2A, C15orf1, LANP, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32

• Tested Applications :

  ELISA, WB, IHC-P

• Protein ID :

  730318

• Physical Properties :

  Liquid