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PHAP I Antibody

CAT: 0223-3151-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3151-01Size:0.02 mg
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Background
PHAP I Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
NCBI Gene ID
8125
Swiss Prot
P39687
Accession Number
P39687
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
3151
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
PHAP I Antibody is DEAE purified.
Positive Control
Cat. No. 1207 - Raji Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (85%)
Buffer
PHAP I Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PHAP I antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
This polyclonal antibody has no cross-reaction to PHAP I2a and PHAP III.
Symbol
ANP32A
Positive Control 2
Cat. No. 1416 - Mouse Testis Tissue Lysate
Positive Control 3
Cat. No. 1476 - Rat Testis Tissue Lysate
Positive Control 4
Cat. No. 1408 - Mouse Small Intestine Tissue Lysate
NCBI Official Name
Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
NCBI Organism
Homo sapiens
Background Reference 01
Jiang et al. Science. 2003;299 (5604) :223-6.
Background Reference 02
Nicholson and Thornberry. Science. 2003 10;299 (5604) :214-5.
Citation 01
16489023
Citation 02
23652204
Citation 03
Parrish. Regulation of Apoptosis Following Mitochondrial Cytochrome c Release. Department of Pharmacology and Molecular Cancer Biology, Duke University. PhD Thesis, 2010.
Other Product Names
PHAP I Antibody: LANP, MAPM, PP32, HPPCn, PHAP1, PHAPI, I1PP2A, C15orf1, LANP, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
730318
Physical Properties
Liquid

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