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PHAP III Antibody

CAT: 0223-3147-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-3147-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PHAP III Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
NCBI Gene ID
81611
Swiss Prot
Q9BTT0
Accession Number
NP_112182
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
PHAP III Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1203 - A549 Cell Lysate
Concentration
1 mg/mL
Buffer
PHAP III Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PHAP III antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures..
Calculated Molecular Weight
35 kDa
Fragment
IgG
Specificity
PHAP III has no cross-reaction to PHAP I and PHAP I2a.
Symbol
ANP32E
Positive Control 2
Cat. No. 1211 - HepG2 Cell Lysate
Positive Control 3
Cat. No. 1308 - Human Small Intestine Tissue Lysate
Positive Control 4
Cat. No. 11-801 - Human Small Intestine Tissue Slide
NCBI Official Name
Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
NCBI Organism
Homo sapiens
Background Reference 01
Jiang X, Kim HE, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng SC , Rosenberg S, Wang X. Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science. 2003;299 (5604) :223-6.
Background Reference 02
Nicholson DW, Thornberry NA. Apoptosis. Life and death decisions. Science. 2003 10;299 (5604) :214-5.
Other Product Names
PHAP III Antibody: LANPL, LANP-L, Acidic leucine-rich nuclear phosphoprotein 32 family member E, LANP-like protein
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
13569879
Physical Properties
Liquid

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