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PLOD3 Antibody

CAT: 0223-56-612Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-612Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity.
NCBI Gene ID
8985
Swiss Prot
O60568
Accession Number
O60568
Host
Rabbit
Reactivity
Human
Immunogen
This PLOD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-105 amino acids from the N-terminal region of human PLOD3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
85 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PLOD3
NCBI Official Name
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
NCBI Organism
Homo sapiens
Background Reference 01
Wang, C., et al. J. Cell. Mol. Med. 13 (3) :508-521 (2009)
Background Reference 02
Salo, A.M., et al. Am. J. Hum. Genet. 83 (4) :495-503 (2008)
Background Reference 03
Salo, A.M., et al. J. Cell. Physiol. 207 (3) :644-653 (2006)
Background Reference 04
Wang, C., et al. Matrix Biol. 21 (7) :559-566 (2002)
Other Product Names
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3, Lysyl hydroxylase 3, LH3, PLOD3
Tested Applications
WB
Physical Properties
Liquid

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