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PLOD1 Antibody

CAT: 0223-56-571Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-571Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity.
NCBI Gene ID
5351
Swiss Prot
Q02809
Accession Number
Q02809
Host
Rabbit
Reactivity
Human
Immunogen
This PLOD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human PLOD1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
84 kDa
Fragment
Rabbit Ig
Symbol
PLOD1
NCBI Official Name
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
NCBI Organism
Homo sapiens
Background Reference 01
Johnatty, S.E., et al. PLoS Genet. (7), E1001016 (2010) :
Background Reference 02
Huang, Q.Y., et al. Bone 44 (5) :984-988 (2009)
Background Reference 03
Yamada, Y., et al. Int. J. Mol. Med. 19 (5) :791-801 (2007)
Background Reference 04
Tasker, P.N., et al. Osteoporos Int 17 (7) :1078-1085 (2006)
Other Product Names
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1, Lysyl hydroxylase 1, LH1, PLOD1, LLH, PLOD
Tested Applications
WB, IHC-P, Flow
Protein ID
78099790
Physical Properties
Liquid

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