PLOD2 Antibody

• Background:

  The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

• NCBI Gene ID:

  5352

• Swiss Prot:

  O00469

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 470-650 of human PLOD2 (NP_891988.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Fragment:

  IgG

• Applications Notes:

  IF: 1:50 - 1:100

• Symbol:

  PLOD2

• NCBI Official Name:

  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  BRKS2, LH2, TLH, procollagen-lysine,2-oxoglutarate 5-dioxygenase 2, lysine hydroxylase 2, lysyl hydroxlase 2, lysyl hydroxylase 2, procollagen-lysine 5-dioxygenase, telopeptide lysyl hydroxylase

• Tested Applications:

  IF

• Physical Properties:

  Liquid