CDKN2C Antibody

• Background:

  The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.

• NCBI Gene ID:

  1031

• Swiss Prot:

  P42773

• Accession Number:

  P42773

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This CDKN2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-139 amino acids from the C-terminal region of human CDKN2C.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  18 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CDKN2C

• NCBI Official Name:

  Cyclin-dependent kinase 4 inhibitor C

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Stratakis, C., et al. Clin. Genet. 78 (5) :457-463 (2010)

• Background Reference 02:

  Cunningham, J.M., et al. Br. J. Cancer 101 (8) :1461-1468 (2009)

• Background Reference 03:

  Eguchi, T., et al. Mol. Cancer Ther. 8 (6) :1460-1472 (2009)

• Background Reference 04:

  Pei, X.H., et al. Cancer Cell 15 (5) :389-401 (2009)

• Other Product Names:

  Cyclin-dependent kinase 4 inhibitor C, Cyclin-dependent kinase 6 inhibitor, p18-INK4c, p18-INK6, CDKN2C, CDKN6

• Tested Applications:

  WB, IHC-P

• Protein ID:

  1168870

• Physical Properties:

  Liquid