CDKN2C Antibody

CAT: 0223-55-525Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-55-525Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
NCBI Gene ID
1031
Swiss Prot
P42773
Accession Number
P42773
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This CDKN2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-139 amino acids from the C-terminal region of human CDKN2C.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
18 kDa
Fragment
Rabbit Ig
Symbol
CDKN2C
NCBI Official Name
Cyclin-dependent kinase 4 inhibitor C
NCBI Organism
Homo sapiens
Background Reference 01
Stratakis, C., et al. Clin. Genet. 78 (5) :457-463 (2010)
Background Reference 02
Cunningham, J.M., et al. Br. J. Cancer 101 (8) :1461-1468 (2009)
Background Reference 03
Eguchi, T., et al. Mol. Cancer Ther. 8 (6) :1460-1472 (2009)
Background Reference 04
Pei, X.H., et al. Cancer Cell 15 (5) :389-401 (2009)
Other Product Names
Cyclin-dependent kinase 4 inhibitor C, Cyclin-dependent kinase 6 inhibitor, p18-INK4c, p18-INK6, CDKN2C, CDKN6
Tested Applications
WB, IHC-P
Protein ID
1168870
Physical Properties
Liquid

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