CDKN2C Antibody

• Background:

  The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.

• NCBI Gene ID:

  1031

• Swiss Prot:

  P42773

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human CDKN2C (NP_523240.1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  293T

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 18kDa

• Fragment:

  IgG

• Symbol:

  CDKN2C

• Positive Control 2:

  HeLa

• Positive Control 3:

  MCF7

• Positive Control 4:

  A-549

• Positive Control 5:

  Mouse testis

• Positive Control 6:

  Rat skeletal muscle

• NCBI Official Name:

  Cyclin-dependent kinase 4 inhibitor C

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Cyclin-dependent kinase 4 inhibitor C, Cyclin-dependent kinase 6 inhibitor, p18-INK4c, p18-INK6, CDKN2C, CDKN6

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid