CDKN2A Antibody

CAT: 0223-24-023Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-24-023Size:100 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
NCBI Gene ID
1029
Swiss Prot
P42771; Q8N726
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 20 to the C-terminus of human CDKN2A / p16INK4a
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Homeostasis, Cancer
Purification
Affinity purification
Positive Control
293T
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 17kDa
Fragment
IgG
Symbol
CDKN2A
Positive Control 2
PC-3
Positive Control 3
HeLa
Positive Control 4
MCF7
NCBI Official Name
Cyclin dependent kinase inhibitor 2A
NCBI Organism
Homo sapiens
Other Product Names
CDKN2A Antibody: ARF, MLM, P14, P16, P19, CMM2, INK4, MTS1, TP16, CDK4I, CDKN2, INK4A, MTS-1, P19ARF, P16INK4, P16INK4A, P16-INK4A, Cyclin-dependent kinase 4 inhibitor A
Tested Applications
WB, IHC, IF
Physical Properties
Liquid

Related Products

CatalogName
13-896CDKN2A / p16INK4a Antibody
14-191CDKN2A / p16INK4a Antibody
8975PCDKN2A Peptide
4211PCDKN2A Peptide
42-917PCdkn2a Peptide
42-131PCDKN2A Peptide
45-033PCDKN2A Peptide
56-550CDKN2B Antibody
14-025CDKN1A Antibody
55-525CDKN2C Antibody

Alternative Products

CatalogName
F47388-0.08MLCDKN2A Antibody

Popular Products