DCC Antibody

CAT: 0223-56-355Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-355Size:400 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
NCBI Gene ID
1630
Swiss Prot
P43146
Accession Number
P43146
Host
Rabbit
Reactivity
Mouse
Immunogen
This DCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 643-670 amino acids from the Central region of human DCC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
158 kDa
Fragment
Rabbit Ig
Symbol
DCC
NCBI Official Name
Netrin receptor DCC
NCBI Organism
Homo sapiens
Background Reference 01
Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)
Background Reference 02
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 03
Srour, M., et al. Science 328 (5978), 592 (2010) :
Background Reference 04
Docherty, S.J., et al. BMC Genet. 11, 61 (2010) :
Other Product Names
Netrin receptor DCC, Colorectal cancer suppressor, Immunoglobulin superfamily DCC subclass member 1, Tumor suppressor protein DCC, DCC, IGDCC1
Tested Applications
WB, IHC-P
Protein ID
296434474
Physical Properties
Liquid

Related Products

CatalogName
11-185Netrin receptor DCC / DCC Recombinant Protein
11-111Netrin receptor DCC / DCC Recombinant Protein
61-567DCC1 Antibody
61-568DCC1 Antibody
13-349WAS Antibody
60-596WAS Antibody
64-160WAS Antibody
61-490TRF Antibody
61-482PPAT Antibody
61-478OPRS1 Antibody

Alternative Products

CatalogName
MBS850197-01Antibody to IGFBP2 Antibody
MBS8529199-01H2B Antibody Antibody
DF8746-01ASAP1 antibody Antibody
MBS8513599-01CD11b Antibody Antibody
E36403ZNF98 Antibody Antibody
MBS9403836-01SZT2 Antibody Antibody
E8M1007-4HSP60 Antibody Antibody
GWB-250026Lck antibody Antibody
LSMab09882anti-Antibody^Polyclonal antibody control antibody
AN100003PPAK1 Antibody Polyclonal Antibody

Popular Products