Netrin receptor DCC / DCC Recombinant Protein

• Background:

  Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

• NCBI Gene ID:

  1630

• Swiss Prot:

  P43146

• Accession Number:

  NP_005206.2

• Tag:

  His Tag

• Type:

  Recombinant Proteins

• Source:

  HEK293 cells

• Purity:

  >95% as determined by SDS-PAGE.

• Buffer:

  PBS, pH7.4

• Shipping Conditions:

  Room Temp

• Storage Conditions:

  Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

• Calculated Molecular Weight:

  119.6 kDa

• Applications Notes:

  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 119.6 kDa. The protein migrates as 125-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

• NCBI Official Name:

  DCC netrin 1 receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  K Keino-Masu, et al. Cell. 1996. 87 (2) :175-85.

• Background Reference 02:

  S Miyake, et al. Cancer Res. 1994. 54 (11) :3007-10.

• Other Product Names:

  Netrin receptor DCC, DCC, IGDCC1, netrin receptor DCC

• Tested Applications:

  WB

• Species:

  Human

• Physical Properties:

  Lyophilized

• CAS Number:

  9000-83-3