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DVL1 Antibody

CAT: 0223-56-349Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-349Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
NCBI Gene ID
1855
Swiss Prot
O14640
Accession Number
O14640
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-470 amino acids from the Central region of human DVL1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
75 kDa
Fragment
Rabbit Ig
Symbol
DVL1
NCBI Official Name
Segment polarity protein dishevelled homolog DVL-1
NCBI Organism
Homo sapiens
Background Reference 01
Metcalfe, C., et al. J. Cell. Sci. 123 (PT 9), 1588-1599 (2010) :
Background Reference 02
Hu, T., et al. J. Biol. Chem. 285 (18) :13561-13568 (2010)
Background Reference 03
Varelas, X., et al. Dev. Cell 18 (4) :579-591 (2010)
Background Reference 04
Jugessur, A., et al. PLoS ONE (7), E11493 (2010) :
Other Product Names
Segment polarity protein dishevelled homolog DVL-1, Dishevelled-1, DSH homolog 1, DVL1
Tested Applications
WB, IHC-P, IF
Physical Properties
Liquid

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