DVL2 Antibody

• Background:

  This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.

• NCBI Gene ID:

  1856

• Swiss Prot:

  O14641

• Accession Number:

  O14641

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DVL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-617 amino acids from the C-terminal region of human DVL2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  79 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DVL2

• NCBI Official Name:

  Segment polarity protein dishevelled homolog DVL-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Inkster, B., et al. Neuroimage 53 (3) :908-917 (2010)

• Background Reference 02:

  Kikuchi, K., et al. EMBO J. 29 (20) :3470-3483 (2010)

• Background Reference 03:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 04:

  Gao, C., et al. Nat. Cell Biol. 12 (8) :781-790 (2010)

• Other Product Names:

  Segment polarity protein dishevelled homolog DVL-2, Dishevelled-2, DSH homolog 2, DVL2

• Tested Applications:

  WB

• Physical Properties:

  Liquid