GDF5 Antibody

• Background:

  The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.

• NCBI Gene ID:

  8200

• Swiss Prot:

  P43026

• Accession Number:

  P43026

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GDF5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-371 amino acids from the C-terminal region of human GDF5.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  55 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GDF5

• NCBI Official Name:

  Growth/differentiation factor 5

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Posthumus, M., et al. Rheumatology (Oxford) 49 (11) :2090-2097 (2010)

• Background Reference 02:

  Rouault, K., et al. Osteoarthr. Cartil. 18 (9) :1144-1149 (2010)

• Background Reference 03:

  Zintzaras, E., et al. Am. J. Epidemiol. 171 (8) :851-858 (2010)

• Background Reference 04:

  Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)

• Other Product Names:

  Growth/differentiation factor 5, GDF-5, Bone morphogenetic protein 14, BMP-14, Cartilage-derived morphogenetic protein 1, CDMP-1, Lipopolysaccharide-associated protein 4, LAP-4, LPS-associated protein 4, Radotermin, GDF5, BMP14, CDMP1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  20141384

• Physical Properties:

  Liquid