GDF1 Antibody

• Background:

  GDF1 Antibody: Growth differentiation factors (GDFs) are members of the transforming growth factor (TGF) superfamily that is involved in embryonic development and adult tissue homeostasis. GDF1 was initially identified as a temporally expressed gene in the mouse central nervous system during embryonic development, with only one isoform detected in adult tissues. GDF1 is required for left-right patterning during development and directly interacts with Nodal, another member of the TGF-beta superfamily. It has been suggested that GDF1 regulates the activity and signaling range of Nodal through direct interaction.

• NCBI Gene ID:

  2657

• Swiss Prot:

  P27539

• Accession Number:

  NP_001483

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  GDF1 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1462 - Rat Lung Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  GDF1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  GDF1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  41 kDa

• Fragment:

  IgG

• Specificity:

  GDF1 antibody is predicted to not cross-react with any other members of the growth differentiation factor family.

• Symbol:

  GDF1

• Positive Control 2:

  Cat. No. 10-101 - Human Lung Tissue Slide

• NCBI Official Name:

  Growth differentiation factor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Massague J. 1990. The transforming growth factor-beta family. Ann. Rev. Cell Biol. 6:597-641.

• Background Reference 02:

  Lee SJ. Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure. Proc. Natl. Acad. Sci. USA 1991; 88:4250-4.

• Background Reference 03:

  Rankin CT, Bunton T, Lawler AM, et al. Regulation of left-right patterning in mice by growth/differentiation factor-1. Nat. Genet. 2000; 24:262-5.

• Background Reference 04:

  Tanaka C, Sakuma R, Nakamura T, et al. Long-range action of Nodal requires interaction with GDF1. Genes Dev. 2007; 21:3272-82.

• Other Product Names:

  GDF1 Antibody: RAI, DORV, DTGA3GDF-1

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  110349792

• Physical Properties:

  Liquid