EDN1 Antibody

• Background:

  The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  1906

• Swiss Prot:

  P05305

• Accession Number:

  P05305

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This EDN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-203 amino acids from the C-terminal region of human EDN1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  24 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  EDN1

• NCBI Official Name:

  Endothelin-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gonsalves, C., et al. J. Immunol. 185 (10) :6253-6264 (2010)

• Background Reference 02:

  Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :

• Background Reference 03:

  Feng, J., et al. Circulation 122 (11 SUPPL), S150-S155 (2010) :

• Background Reference 04:

  Nikopensius, T., et al. Birth Defects Res. PartClin. Mol. Teratol. 88 (9) :748-756 (2010)

• Other Product Names:

  Endothelin-1, Preproendothelin-1, PPET1, Endothelin-1, ET-1, Big endothelin-1, EDN1

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  119610

• Physical Properties:

  Liquid