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EDN3 Antibody

CAT: 0223-55-714Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-714Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB) . The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
NCBI Gene ID
1908
Swiss Prot
P14138
Accession Number
P14138
Host
Rabbit
Reactivity
Human
Immunogen
This EDN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human EDN3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
25 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
EDN3
NCBI Official Name
Endothelin-3
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Darrah, R., et al. Physiol. Genomics 41 (1) :71-77 (2010)
Background Reference 03
Sanchez-Mejias, A., et al. Genet. Med. 12 (1) :39-43 (2010)
Background Reference 04
Broasca, V., et al. RomMorphol Embryol 51 (2) :283-288 (2010)
Other Product Names
Endothelin-3, ET-3, Preproendothelin-3, PPET3, EDN3
Tested Applications
WB
Protein ID
119618
Physical Properties
Liquid

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