EDN3 Antibody

• Background:

  The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB) . The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.

• NCBI Gene ID:

  1908

• Swiss Prot:

  P14138

• Accession Number:

  P14138

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This EDN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human EDN3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  25 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  EDN3

• NCBI Official Name:

  Endothelin-3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Darrah, R., et al. Physiol. Genomics 41 (1) :71-77 (2010)

• Background Reference 03:

  Sanchez-Mejias, A., et al. Genet. Med. 12 (1) :39-43 (2010)

• Background Reference 04:

  Broasca, V., et al. RomMorphol Embryol 51 (2) :283-288 (2010)

• Other Product Names:

  Endothelin-3, ET-3, Preproendothelin-3, PPET3, EDN3

• Tested Applications:

  WB

• Protein ID:

  119618

• Physical Properties:

  Liquid