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MED7 Antibody

CAT: 0223-56-144Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-144Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor- (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
NCBI Gene ID
9443
Swiss Prot
O43513
Accession Number
O43513
Host
Rabbit
Reactivity
Human
Immunogen
This MED7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-111 amino acids from the Central region of human MED7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
27 kDa
Fragment
Rabbit Ig
Symbol
MED7
NCBI Official Name
Mediator of RNA polymerase II transcription subunit 7
NCBI Organism
Homo sapiens
Background Reference 01
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Background Reference 02
Sato, S., et al. Mol. Cell 14 (5) :685-691 (2004)
Background Reference 03
Tomomori-Sato, C., et al. J. Biol. Chem. 279 (7) :5846-5851 (2004)
Background Reference 04
Sato, S., et al. J. Biol. Chem. 278 (17) :15123-15127 (2003)
Other Product Names
Mediator of RNA polymerase II transcription subunit 7, hMED7, Activator-recruited cofactor 34 kDa component, ARC34, Cofactor required for Sp1 transcriptional activation subunit 9, CRSP complex subunit 9, Mediator complex subunit 7, RNA polymerase transcriptional regulation mediator subunit 7 homolog, Transcriptional coactivator CRSP33, MED7, ARC34, CRSP9
Tested Applications
WB, Flow
Physical Properties
Liquid