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MED4 Antibody

CAT: 0223-4729-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-4729-01Size:0.02 mg
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Background
MED4 Antibody: The mediator complex is a multi-protein transcriptional co-activator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factor. One of the proteins in this complex is MED4. This protein has also been shown to be part of the vitamin D receptor interacting complex. MED4 was recently identified as an HIV dependency factor (HDF), suggesting that MED4 may be an important drug target in HIV treatment.
NCBI Gene ID
29079
Swiss Prot
Q9NPJ6
Accession Number
NP_054885
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Infectious Disease
Purification
MED4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1313 - Human Testis Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (86%)
Buffer
MED4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MED4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least three isoforms of MED4 are known to exist; this antibody only recognizes the largest isoform.
Symbol
MED4
Positive Control 2
Cat. No. 11-701 - Human Testis Tissue Slide
NCBI Official Name
Mediator complex subunit 4
NCBI Organism
Homo sapiens
Background Reference 01
Sato S, Tomomori-Sato C, Parmely TJ, et al. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Mol. Cell2004; 14:685-91.
Background Reference 02
Gustafsson CM, Myers LC, Beve J, et al. Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. J. Biol. Chem.1998; 273:30851-4.
Background Reference 03
Rachez C, Lemon BD, Suldan Z, et al. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature1999; 398:824-8.
Background Reference 04
Brass AL, Dykxhoorn DM, Benita Y, et al. Identification of host proteins required for HIV infection through a functional genomic screen. Science2008; 319:921-6.
Other Product Names
MED4 Antibody: ARC36, VDRIP, DRIP36, TRAP36, HSPC126, ARC36, Mediator of RNA polymerase II transcription subunit 4, Activator-recruited cofactor 36 kDa component
Tested Applications
ELISA, WB, IHC-P
Protein ID
7661788
Physical Properties
Liquid

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