GRIN2A Antibody

• Background:

  N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D) . Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  2903

• Swiss Prot:

  Q12879

• Accession Number:

  Q12879

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GRIN2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1291-1318 amino acids from the C-terminal region of human GRIN2A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  165 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GRIN2A

• NCBI Official Name:

  Glutamate receptor ionotropic, NMDA 2A

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Endele, S., et al. Nat. Genet. 42 (11) :1021-1026 (2010)

• Background Reference 02:

  Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

• Background Reference 03:

  Saus, E., et al.Psychiatr Res 44 (14) :971-978 (2010)

• Background Reference 04:

  Pinheiro, A.P., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :

• Other Product Names:

  Glutamate receptor ionotropic, NMDA 2A, GluN2A, Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, NMDAR2A, NR2A, hNR2A, GRIN2A, NMDAR2A

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  14285603

• Physical Properties:

  Liquid