GRINA Antibody

• Background:

  GRINA Antibody: The transmembrane BAX inhibitor motif (TMBIM) family of proteins includes the founder member TMBIM6/BI-1, TMBIM1/RECS1 (responsive to centrifugal force and shear stress gene 1 protein), TMBIM2/LFG (life guard), TMBIM3/GRINA (glutamate receptor ionotropic NMDA protein 1), TMBIM4/GAAP (Golgi anti-apoptotic-associated protein), and TMBIM5/GHTIM (growth hormone-inducible transmembrane protein) . They are highly conserved in mammals and zebrafish and contain a conserved BAX inhibitor-1 motif. GRINA is expressed in the brain and is a potential apoptotic regulator.

• NCBI Gene ID:

  2907

• Swiss Prot:

  Q7Z429

• Accession Number:

  NP_001009184

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis

• Purification:

  GRINA Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1313 - Human Testis Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse: (94%), Rat: (94%), Bovine: (83%)

• Buffer:

  GRINA Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  GRINA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Calculated Molecular Weight:

  Predicted: 41 kDa

• Fragment:

  IgG

• Specificity:

  GRINA antibody is predicted to not cross-react with other members of the TMBIM family.

• Symbol:

  GRINA

• NCBI Official Name:

  Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Yamaji T, Nishikawa K and Hanada K et al. Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis. J. Biol. Chem. 2010; 285:35505-18.

• Background Reference 02:

  Nielsen JA, Chambers MA, Romm E, et al. Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system. Mol. Cell. Biochem. 2011; 357:73-81.

• Background Reference 03:

  Rojas-Rivera D, Armisén R, Colombo A, et al. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ. 2012; 19:1013-26.

• Other Product Names:

  GRINA Antibody: LFG1, HNRGW, TMBIM3, NMDARA1, LFG1, Protein lifeguard 1, NMDA receptor glutamate-binding subunit

• Tested Applications:

  ELISA, WB

• Protein ID:

  57165375

• Physical Properties:

  Liquid