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GRINA Antibody

CAT: 0223-7147-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7147-01Size:0.02 mg
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Background
GRINA Antibody: The transmembrane BAX inhibitor motif (TMBIM) family of proteins includes the founder member TMBIM6/BI-1, TMBIM1/RECS1 (responsive to centrifugal force and shear stress gene 1 protein), TMBIM2/LFG (life guard), TMBIM3/GRINA (glutamate receptor ionotropic NMDA protein 1), TMBIM4/GAAP (Golgi anti-apoptotic-associated protein), and TMBIM5/GHTIM (growth hormone-inducible transmembrane protein) . They are highly conserved in mammals and zebrafish and contain a conserved BAX inhibitor-1 motif. GRINA is expressed in the brain and is a potential apoptotic regulator.
NCBI Gene ID
2907
Swiss Prot
Q7Z429
Accession Number
NP_001009184
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
GRINA Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1313 - Human Testis Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (94%), Rat: (94%), Bovine: (83%)
Buffer
GRINA Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
GRINA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
Predicted: 41 kDa
Fragment
IgG
Specificity
GRINA antibody is predicted to not cross-react with other members of the TMBIM family.
Symbol
GRINA
NCBI Official Name
Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
NCBI Organism
Homo sapiens
Background Reference 01
Yamaji T, Nishikawa K and Hanada K et al. Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis. J. Biol. Chem. 2010; 285:35505-18.
Background Reference 02
Nielsen JA, Chambers MA, Romm E, et al. Mouse transmembrane BAX inhibitor motif 3 (Tmbim3) encodes a 38 kDa transmembrane protein expressed in the central nervous system. Mol. Cell. Biochem. 2011; 357:73-81.
Background Reference 03
Rojas-Rivera D, Armisén R, Colombo A, et al. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ. 2012; 19:1013-26.
Other Product Names
GRINA Antibody: LFG1, HNRGW, TMBIM3, NMDARA1, LFG1, Protein lifeguard 1, NMDA receptor glutamate-binding subunit
Tested Applications
ELISA, WB
Protein ID
57165375
Physical Properties
Liquid

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