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H2AFZ Antibody

CAT: 0223-55-724Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-724Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4) . The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq].
NCBI Gene ID
3015
Swiss Prot
P0C0S5
Accession Number
P0C0S5
Host
Rabbit
Reactivity
Human
Immunogen
This H2AFZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-86 amino acids from the C-terminal region of human H2AFZ.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, C. Elegans, Chicken, Zebrafish, Drosophila, Mouse, Rabbit, Xenopus, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
14 kDa
Fragment
Rabbit Ig
Symbol
H2AFZ
NCBI Official Name
Histone H2A.Z
NCBI Organism
Homo sapiens
Background Reference 01
Marques, M., et al. Epigenetics 5 (4) :267-272 (2010)
Background Reference 02
Svotelis, A., et al. Cell Cycle 9 (2) :364-370 (2010)
Background Reference 03
Thakar, A., et al. Biochemistry 48 (46) :10852-10857 (2009)
Background Reference 04
Hardy, S., et al. PLoS Genet. (10), E1000687 (2009) :
Other Product Names
Histone H2AZ, H2A/z, H2AFZ, H2AZ
Tested Applications
WB, IHC-P
Protein ID
83288408
Physical Properties
Liquid

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