SNAP25 Antibody

• Background:

  SNAP25 (Synaptosomal associated protein of 25 kDa) is a presynaptic plasma membrane protein that is widely distributed throughout the brain and involved in the regulation of neurotransmitter release. Decreased levels of SNAP25 have been found in the brains of patients with Down Syndrome and Alzheimer’s Disease (Greber et al.,1999) . In addition, a significant reduction in the hippocampal expression of SNAP25 has also been found in patients with Schizophrenia (Fatemi et al., 2001) .

• NCBI Gene ID:

  25012

• Swiss Prot:

  P60881

• Accession Number:

  P60881

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Dog, Zebrafish, Goat, Bovine, Chicken

• Immunogen:

  Peptide corresponding to amino acid residues from the C-terminal region of rat SNAP25 conjugated to keyhole limpet hemocyanin (KLH) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity Purified

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  SNAP25 antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

• Calculated Molecular Weight:

  25

• Symbol:

  Snap25

• NCBI Official Name:

  Synaptosomal-associated protein 25

• NCBI Organism:

  Rattus norvegicus

• Background Reference 01:

  Fatemi SH, Sidwell R, Kist D, Akhter P, Meltzer HY, Bailey K, Thuras P, Sedgwick J (1998) Differential expression of synaptosome-associated protein 25 kDa (Snap25) in hippocampi of neonatal mice following exposure to human influenza virus in utero. Brain Res 800 (1) :1-9..

• Background Reference 02:

  Greber S, Cairns N, Lubec G, Fountoulakis M (1999) Decreased levels of the synaptosomal associated protein 25 in the brains of patients with Down Syndrome and Alzheimer’s Disease. Electrophoresis 20 (4-5) :928-34.

• Background Reference 03:

  Ando K, Kudo Y, Takahashi M (2005) Negative regulation of neurotransmitter release by calpain: a possible specific involvement of Snap25 cleavage. J Neurochem 94 (3) :651-8.

• Tested Applications:

  WB

• Protein ID:

  46397720

• Physical Properties:

  Liquid