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PCDH18 Antibody

CAT: 0223-5081-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-5081-01Size:0.02 mg
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Background
PCDH18 Antibody: Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 18 (PCDH18) was initially identified through screening of human and mouse ESTs using conserved cytoplasmic domain motifs. Tissue screening revealed PCDH18 broad expression in tissues such as brain, liver, heart, kidney, lung, and trachea. PCDH18 expression is also temporally and spatially regulated in the mouse embryonic brain and interacts with Disabled-1, an intracellular adapter protein involved in neuronal migration and cell positioning during mammalian brain development. PCDH18 was also found to be expressed in the developing zebrafish neural tube and central nervous system, lending support to the hypothesis that PCDH18 may play a role during brain development.
NCBI Gene ID
54510
Swiss Prot
Q9HCL0
Accession Number
NP_061908
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
PCDH18 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1211 - HepG2 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (95%)
Buffer
PCDH18 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PCDH18 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least three isoforms of PCDH18 are known to exist. This antibody is predicted to not cross-react with PCDH12.
Symbol
PCDH18
NCBI Official Name
Protocadherin 18
NCBI Organism
Homo sapiens
Background Reference 01
Frank M and Kemler R. Protocadherins. Curr. Opin. Cell Biol.2002; 14:557-62.
Background Reference 02
Wolverton T and Lalande M. Identification and characterization of three members of a novel subclass of protocadherins. Genomics2001; 76:66-72.
Background Reference 03
Homayouni R, Rice DS, and Curran T. Disabled-1 interacts with a novel developmentally regulated protocadherin. Biochem. Biophys. Res. Commun.2001; 289:539-47.
Background Reference 04
Kubota F, Murakami T, Tajika Y, et al. Expression of protocadherin 18 in the CNS and pharyngeal arches of zebrafish embryos. Int. J. Dev. Biol.2008; 52:397-405.
Other Product Names
PCDH18 Antibody: PCDH68L, KIAA1562, Protocadherin-18
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
14589929
Physical Properties
Liquid

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