PCDH18 Antibody

• Background:

  PCDH18 Antibody: Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 18 (PCDH18) was initially identified through screening of human and mouse ESTs using conserved cytoplasmic domain motifs. Tissue screening revealed PCDH18 broad expression in tissues such as brain, liver, heart, kidney, lung, and trachea. PCDH18 expression is also temporally and spatially regulated in the mouse embryonic brain and interacts with Disabled-1, an intracellular adapter protein involved in neuronal migration and cell positioning during mammalian brain development. PCDH18 was also found to be expressed in the developing zebrafish neural tube and central nervous system, lending support to the hypothesis that PCDH18 may play a role during brain development.

• NCBI Gene ID:

  54510

• Swiss Prot:

  Q9HCL0

• Accession Number:

  NP_061908

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  PCDH18 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1211 - HepG2 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (95%)

• Buffer:

  PCDH18 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  PCDH18 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Specificity:

  At least three isoforms of PCDH18 are known to exist. This antibody is predicted to not cross-react with PCDH12.

• Symbol:

  PCDH18

• NCBI Official Name:

  Protocadherin 18

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Frank M and Kemler R. Protocadherins. Curr. Opin. Cell Biol.2002; 14:557-62.

• Background Reference 02:

  Wolverton T and Lalande M. Identification and characterization of three members of a novel subclass of protocadherins. Genomics2001; 76:66-72.

• Background Reference 03:

  Homayouni R, Rice DS, and Curran T. Disabled-1 interacts with a novel developmentally regulated protocadherin. Biochem. Biophys. Res. Commun.2001; 289:539-47.

• Background Reference 04:

  Kubota F, Murakami T, Tajika Y, et al. Expression of protocadherin 18 in the CNS and pharyngeal arches of zebrafish embryos. Int. J. Dev. Biol.2008; 52:397-405.

• Other Product Names:

  PCDH18 Antibody: PCDH68L, KIAA1562, Protocadherin-18

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  14589929

• Physical Properties:

  Liquid