PSD-95 Antibody

• Background:

  PSD-95 is a very prominent component of the postsynaptic densities of synapses. It contains three PDZ domains which play key roles in its interactions with other proteins in the synapse. It has been proposed that these PDZ domains organize glutamate receptors and their associated signaling proteins and determine the size and strength of synapses (Kim and Sheng, 2004) . Recent work suggests that interaction of the NMDAR with PSD-95 via these PDZ domains can be regulated by phosphorylation (Chung et al., 2004) .

• NCBI Gene ID:

  29495

• Swiss Prot:

  P31016

• Accession Number:

  P31016

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat, Bovine, Zebrafish

• Immunogen:

  Peptide corresponding to amino acid residues from the N-terminal region of rat PSD-95, conjugated to keyhole limpet hemocyanin (KLH) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity Purified

• Concentration:

  Batch dependent

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  PSD-95 antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.

• Calculated Molecular Weight:

  95

• Applications Notes:

  The antibody has been directly tested for reactivity in Western blots in rat and mouse tissues. It is anticipated that the antibody will also work with bovine, human, mouse, non-human primates and zebra fish tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

• Symbol:

  Dlg4

• NCBI Official Name:

  Discs, large homolog 4 (Drosophila)

• NCBI Organism:

  Rattus norvegicus

• Background Reference 01:

  Scannevin RH, Huganir RL (2000) Postsynaptic organization and regulation of excitatory synapses. Nat Rev Neurosci 1:133-141.

• Background Reference 02:

  Ye B, Liao DZ, Zhang XQ, Zhang PS, Dong HL, Huganir RL (2000) GRASP-1: A neuronal RasGEF associated with the AMPA receptor/GRIP complex. Neuron 26:603-617.

• Tested Applications:

  WB

• Protein ID:

  400891

• Physical Properties:

  Liquid