SCN1B Antibody

• Background:

  Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  6324

• Swiss Prot:

  Q07699

• Accession Number:

  Q07699

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This SCN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human SCN1B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Rabbit, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  25 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SCN1B

• NCBI Official Name:

  Sodium channel subunit beta-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Grover, S., et al. Pharmacogenomics 11 (7) :927-941 (2010)

• Background Reference 02:

  Tan, B.H., et al. Heart Rhythm 7 (6) :771-778 (2010)

• Background Reference 03:

  Casini, S., et al. Cardiovasc. Res. 85 (4) :691-700 (2010)

• Background Reference 04:

  Ogawa, R., et al. IntClin Pharmacol Ther 48 (2) :109-119 (2010)

• Other Product Names:

  Sodium channel subunit beta-1, SCN1B

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  1705868

• Physical Properties:

  Liquid