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SCN1B Antibody

CAT: 0223-55-309Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-309Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
6324
Swiss Prot
Q07699
Accession Number
Q07699
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This SCN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human SCN1B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Rabbit, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
25 kDa
Fragment
Rabbit Ig
Symbol
SCN1B
NCBI Official Name
Sodium channel subunit beta-1
NCBI Organism
Homo sapiens
Background Reference 01
Grover, S., et al. Pharmacogenomics 11 (7) :927-941 (2010)
Background Reference 02
Tan, B.H., et al. Heart Rhythm 7 (6) :771-778 (2010)
Background Reference 03
Casini, S., et al. Cardiovasc. Res. 85 (4) :691-700 (2010)
Background Reference 04
Ogawa, R., et al. IntClin Pharmacol Ther 48 (2) :109-119 (2010)
Other Product Names
Sodium channel subunit beta-1, SCN1B
Tested Applications
WB, IHC-P, Flow
Protein ID
1705868
Physical Properties
Liquid

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