UBE1C Antibody

• Background:

  The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

• NCBI Gene ID:

  9039

• Swiss Prot:

  Q8TBC4

• Accession Number:

  Q8TBC4

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This UBE1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 415-445 amino acids from the C-terminal region of human UBE1C.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Zebrafish, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  52 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  UBA3

• NCBI Official Name:

  NEDD8-activating enzyme E1 catalytic subunit

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bohnsack, R.N., et al., J. Biol. Chem. 278 (29) :26823-26830 (2003) .

• Background Reference 02:

  Walden, H., et al., Nature 422 (6929) :330-334 (2003) .

• Background Reference 03:

  Gong, L., et al., J. Biol. Chem. 274 (17) :12036-12042 (1999) .

• Background Reference 04:

  Gubin, A.N., et al., Genomics 59 (2) :168-177 (1999) .

• Other Product Names:

  NEDD8-activating enzyme E1 catalytic subunit, 632-, NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C, Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3, UBA3, UBE1C

• Tested Applications:

  WB, IHC-P

• Protein ID:

  83305811

• Physical Properties:

  Liquid