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UBE1C Antibody

CAT: 0223-55-304Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-304Size:400 µL
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Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
NCBI Gene ID
9039
Swiss Prot
Q8TBC4
Accession Number
Q8TBC4
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This UBE1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 415-445 amino acids from the C-terminal region of human UBE1C.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Zebrafish, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
52 kDa
Fragment
Rabbit Ig
Symbol
UBA3
NCBI Official Name
NEDD8-activating enzyme E1 catalytic subunit
NCBI Organism
Homo sapiens
Background Reference 01
Bohnsack, R.N., et al., J. Biol. Chem. 278 (29) :26823-26830 (2003) .
Background Reference 02
Walden, H., et al., Nature 422 (6929) :330-334 (2003) .
Background Reference 03
Gong, L., et al., J. Biol. Chem. 274 (17) :12036-12042 (1999) .
Background Reference 04
Gubin, A.N., et al., Genomics 59 (2) :168-177 (1999) .
Other Product Names
NEDD8-activating enzyme E1 catalytic subunit, 632-, NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C, Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3, UBA3, UBE1C
Tested Applications
WB, IHC-P
Protein ID
83305811
Physical Properties
Liquid

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