WDR48 Antibody

• Background:

  Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP) . Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.

• NCBI Gene ID:

  57599

• Swiss Prot:

  Q8TAF3

• Accession Number:

  Q8TAF3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This WDR48 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-630 amino acids from the C-terminal region of human WDR48.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  76 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  WDR48

• NCBI Official Name:

  WD repeat-containing protein 48

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kee, Y., et al. J. Biol. Chem. 285 (15) :11252-11257 (2010)

• Background Reference 02:

  Cohn, M.A., et al. J. Biol. Chem. 284 (8) :5343-5351 (2009)

• Background Reference 03:

  Cote-Martin, A., et al. J. Virol. 82 (3) :1271-1283 (2008)

• Background Reference 04:

  Cohn, M.A., et al. Mol. Cell 28 (5) :786-797 (2007)

• Other Product Names:

  WD repeat-containing protein 48, USP1-associated factor 1, WD repeat endosomal protein, p80, WDR48, KIAA1449, UAF1

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  74760390

• Physical Properties:

  Liquid