Products for Research Use Only
RegisterLogin

WDR48 Antibody

CAT: 0223-55-224Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-55-224Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP) . Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.
NCBI Gene ID
57599
Swiss Prot
Q8TAF3
Accession Number
Q8TAF3
Host
Rabbit
Reactivity
Human
Immunogen
This WDR48 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 603-630 amino acids from the C-terminal region of human WDR48.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
76 kDa
Fragment
Rabbit Ig
Symbol
WDR48
NCBI Official Name
WD repeat-containing protein 48
NCBI Organism
Homo sapiens
Background Reference 01
Kee, Y., et al. J. Biol. Chem. 285 (15) :11252-11257 (2010)
Background Reference 02
Cohn, M.A., et al. J. Biol. Chem. 284 (8) :5343-5351 (2009)
Background Reference 03
Cote-Martin, A., et al. J. Virol. 82 (3) :1271-1283 (2008)
Background Reference 04
Cohn, M.A., et al. Mol. Cell 28 (5) :786-797 (2007)
Other Product Names
WD repeat-containing protein 48, USP1-associated factor 1, WD repeat endosomal protein, p80, WDR48, KIAA1449, UAF1
Tested Applications
WB, IHC-P, Flow
Protein ID
74760390
Physical Properties
Liquid

Related Products

CatalogName
55-477WDR41 Antibody
57-122WDR88 Antibody
61-948WDR43 Antibody
6817-002mgWDR18 Antibody
55-482WDR49 Antibody
23-041WDR45 Antibody
59-117WDR68 Antibody
56-982WDR45 Antibody
26-783WDR49 Antibody
6817-01WDR18 Antibody

Alternative Products

CatalogName
MBS9629580-01WDR48 Antibody
STJ28936Anti-WDR48 antibody
BS70745-01WDR48 polyclonal antibody
MBS8536105-01WDR48

Popular Products