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ACTL7A Antibody

CAT: 0223-55-197Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-55-197Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ACTL7A is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. ACTL7A (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known.
NCBI Gene ID
10881
Swiss Prot
Q9Y615
Accession Number
Q9Y615
Host
Rabbit
Reactivity
Human
Immunogen
This ACTL7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-67 amino acids from the N-terminal region of human ACTL7A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
49 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ACTL7A
NCBI Official Name
Actin-like protein 7A
NCBI Organism
Homo sapiens
Background Reference 01
Aberg, K., et al. Hum. Biol. 80 (2) :99-123 (2008)
Background Reference 02
Humphray, S.J., et al. Nature 429 (6990) :369-374 (2004)
Background Reference 03
Garvalov, B.K., et al. J. Cell Biol. 161 (1) :33-39 (2003)
Background Reference 04
Coutts, A.S., et al. J. Cell. Sci. 116 (PT 5), 897-906 (2003) :
Other Product Names
Actin-like protein 7A, Actin-like-7-alpha, ACTL7A
Tested Applications
WB
Protein ID
27923725
Physical Properties
Liquid

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