ACTL6B Antibody

• Background:

  ACTL6B is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.

• NCBI Gene ID:

  51412

• Swiss Prot:

  O94805

• Accession Number:

  O94805

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ACTL6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human ACTL6B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  47 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ACTL6B

• NCBI Official Name:

  Actin-like protein 6B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Oma, Y., et al. Biochem. Biophys. Res. Commun. 301 (2) :521-528 (2003)

• Background Reference 02:

  Kuroda, Y., et al. Biochem. Biophys. Res. Commun. 299 (2) :328-334 (2002)

• Background Reference 03:

  Olave, I., et al. Genes Dev. 16 (19) :2509-2517 (2002)

• Other Product Names:

  Actin-like protein 6B, 53 kDa BRG1-associated factor B, Actin-related protein Baf53b, ArpNalpha, BRG1-associated factor 53B, BAF53B, ACTL6B, ACTL6, BAF53B

• Tested Applications:

  WB, IHC-P, Flow

• Physical Properties:

  Liquid