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ACTR1A Antibody

CAT: 0223-58-272Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-272Size:400 µL
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Background
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin.
NCBI Gene ID
10121
Swiss Prot
P61163
Accession Number
P61163
Host
Rabbit
Reactivity
Mouse
Immunogen
This ACTR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the Central region of human ACTR1A.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
43 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ACTR1A
NCBI Official Name
Alpha-centractin
NCBI Organism
Homo sapiens
Background Reference 01
Sugarbaker, D.J., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (9) :3521-3526 (2008)
Background Reference 02
Petretti, C., et al. EMBO Rep. 7 (4) :418-424 (2006)
Background Reference 03
Casenghi, M., et al. Dev. Cell 5 (1) :113-125 (2003)
Background Reference 04
Carew, J.A., et al. J. Thromb. Haemost. 1 (6) :1220-1227 (2003)
Other Product Names
Alpha-centractin, Centractin, ARP1, Actin-RPV, Centrosome-associated actin homolog, ACTR1A, CTRN1
Tested Applications
WB
Protein ID
47117651
Physical Properties
Liquid

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