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ACTL7B Antibody

CAT: 0223-58-536Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-536Size:400 µL
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Background
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.
NCBI Gene ID
10880
Swiss Prot
Q9Y614
Accession Number
Q9Y614
Host
Rabbit
Reactivity
Human
Immunogen
This ACTL7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-97 amino acids from the N-terminal region of human ACTL7B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
45 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ACTL7B
NCBI Official Name
Actin-like protein 7B
NCBI Organism
Homo sapiens
Background Reference 01
Humphray, S.J., et al. Nature 429 (6990) :369-374 (2004)
Background Reference 02
Hisano, M., et al. Nucleic Acids Res. 31 (16) :4797-4804 (2003)
Background Reference 03
Chadwick, B.P., et al. Genomics 58 (3) :302-309 (1999)
Background Reference 04
Schafer, D.A., et al. Annu. Rev. Cell Dev. Biol. 15, 341-363 (1999) :
Other Product Names
Actin-like protein 7B, Actin-like-7-beta, ACTL7B
Tested Applications
WB
Protein ID
27923724
Physical Properties
Liquid

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